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Trauma, Vol. 7, No. 2, 63-68 (2005)
DOI: 10.1191/1460408605ta328oa
© 2005 SAGE Publications

Anticoagulation in the trauma patient

Leena Karnik

Department of Haematology, University Hospitals of Birmingham, Birmingham, UK, leena.karnik{at}bch.nhs.uk

Jim Murray

Department of Haematology, University Hospitals of Birmingham, Birmingham, UK

The trauma patient presents several challenges in areas of anticoagulation and haemostasis. Low molecular weight heparins are the mainstay of thrombopro phylaxis of trauma patients; however, new agents are being studied in trials and may soon be available. Patients already on oral anticoagulation may need reversal using plasma or prothrombin complex concentrates. Heparin-induced thrombo cytopenia needs a high index of suspicion and prompt treatment by clinicians treating trauma patients. Disseminated intravascular coagulation can be seen in the context of major trauma. Correction of the underlying cause and supportive blood component use are the mainstays of treatment.

Key Words: anticoagulationand trauma • heparin • heparin-inducedthrombocytopenia • thromboprophylaxis and trauma • warfarin


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