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Trauma
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Watering down the clots, or are we?

Anthony M Roche

Department of Anesthesiology, Duke University Medical Center, Durham, USA, tony.roche{at}duke.edu

Michael FM James

Department of Anaesthesia, University of Cape Town, Cape Town, South Africa

Fluid resuscitation is an essential part of managing patients with major trauma, as well as in the perioperative setting. Common misconceptions exist regarding the role of fluid therapy in maintaining, enhancing or inhibiting normal coagulation and haemostasis. This review provides an overview of the basic coagulation processes, as well as the influence of intravenous crystalloid and colloid preparations on haemostasis and coagulation. The use of point-of-care devices is encouraged as a feasible way of monitoring these effects in the acute setting.

Key Words: coagulation • colloid • crystalloid • fluids • intravenous • TEG • thrombelastograph

Trauma, Vol. 5, No. 4, 235-244 (2003)
DOI: 10.1191/1460408603ta290oa
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[Abstract] [PDF]


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