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Coagulopathy in trauma: optimising haematological statusHaemostasis Research Unit, University College London, v.mcdonald{at}ucl.ac.uk, Department of Haematology, University College London, London, UK
Haemostasis Research Unit, University College London, v.mcdonald{at}ucl.ac.uk, Department of Haematology, University College London, London, UK It is estimated that 10 000 people per year die following trauma in England and Wales and 30—40% do so due to uncontrolled haemorrhage. By the time the patient reaches hospital, coagulopathy is often already installed and needs to be corrected promptly to prevent further haemorrhage and allow effective treatment of injuries. The coagulopathy is multifactorial with the leading causes being acidosis, hypothermia and massive transfusion. Early recognition of the condition is imperative using standard coagulation testing; however, there are limitations in this setting. Newer methods of testing `global haemostasis' using thromboelastography are becoming more popular but need further validation. Treatment of coagulopathy requires a multidisciplinary approach. Blood product transfusion remains the cornerstone of management but newer pharmacological agents such as recombinant factor VIIa are increasingly being used. Here we review the pathogenesis, investigation and management of the coagulopathy of trauma.
Key Words: Coagulopathy • trauma • lethal triad • transfusion • fresh frozen plasma • platelets • fibrinogen • rVIIa
Trauma, Vol. 10, No. 2,
109-123 (2008) |
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